Northwestern Medicine scientists developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which line blood vessel walls. Published in Cell Reports, this is the first time that vascular endothelial cells could be reached for genome editing, since the usual way to deliver CRISPR/Cas9 – through a virus – does not
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People who contracted COVID-19 while pregnant were more likely to have poor birth outcomes including preterm birth, small for gestational age, low birth weight, and stillbirth. The poor outcomes of preterm birth and stillbirth were observed primarily with those infected with SARS-CoV-2 during the first or second trimester, whereas increased rates of small for gestational
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Childhood sexual abuse can lead to depression, anxiety, cardiovascular disease and other health problems later in life. Not all abused children experience these problems, however, and researchers are working to understand whose health is affected and why. In a new article in the journal Psychoneuroendocrinology, a team of researchers led by faculty in Penn State’s
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In a recent study published on the medRxiv* preprint server, a team of researchers tested the durability of antibodies produced by a vaccine-induced full-length severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and receptor-binding domain (RBD). They also analyzed the antibody levels targeting the SARS-CoV-2 Omicron variant of concern (VOC), in younger adolescent children.
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In this interview, we speak to Paolo De Coppi from Great Ormond Street Hospital, about his latest organoid research and how these lab-grown ‘mini-stomachs’ can be used to investigate COVID-19 symptoms in children. Thought LeadersPaolo De CoppiPediatric SurgeonGreat Ormond Street Hospital Please could you introduce yourself and tell us what inspired your latest research into
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Scientists have worked at an unprecedented speed to develop vaccines to fight against the ongoing coronavirus disease 2019 (COVID-19) pandemic. This pandemic has been caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus belonging to the family Coronaviridae. Study: Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents. Image Credit: NIAID Background It
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A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators was used to diagnose rare genetic diseases in an average of eight hours -; a feat that’s nearly unheard of in standard clinical care. “A few weeks is what most clinicians call ‘rapid’ when it comes to sequencing a patient’s genome
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